> Emotional and Mental Health > Energy and Fatigue

Do you feel tired all the time? Is your hair brittle, your nails weak, or your eyesight poor? If so, you could have a nutritional deficiency. In fact, most people have one or more nutritional deficiencies for a variety of reasons including poor diet (insufficient nutrient intake) or too much stress (depletes nutrients).

Do you feel tired all the time? Is your hair brittle, your nails weak, or your eyesight poor? If so, you could have a nutritional deficiency. In fact, most people have one or more nutritional deficiencies for a variety of reasons including poor diet (insufficient nutrient intake) or too much stress (depletes nutrients).

We now also know that many commonly prescribed drugs cause nutrient depletions, including any estrogen-containing medications, anticonvulsants, antidiabetic, antihypertensive (for high blood pressure), anti-inflammatory and anti-ulcer drugs, cholesterol-lowering drugs, beta-blockers, tricyclic antidepressants, and antibiotics. This, in turn, can cause or contribute to additional health problems. When people take a medication, drug-related side-effects usually occur relatively quickly, within the first 24 to 48 hours or certainly within the first week. However, health problems associated with drug-induced nutrient depletions are much more subtle and insidious. Because they develop gradually over a longer period of time, these health problems are more difficult to identify.

Let’s consider, for example, women who have taken oral contraceptives for a number of years, seemingly without problems. However, gradually and more frequently, they may tell their partners, “I’m so tired, I can hardly get up in the morning,” or “By the middle of the day, I feel like I’ve totally run out of gas,” or “I’m so tired, I can hardly make it through the day.” These women are not likely to realize their symptoms may be caused by oral contraceptive-induced depletion of vitamin B₁₂ and folic acid, which can result in anemia and symptoms of fatigue and weakness.

Folic acid depletion also increases a woman’s risk for a number of diseases such as anemia, birth defects, cervical dysplasia (which may result in a hysterectomy), and elevated levels of homocysteine, which increases risk for cardiovascular disease. More recently, studies have reported folic acid deficiency also increases risk for developing breast and colorectal cancer.

Vitamin B₆ depletion from oral contraceptives interferes with the synthesis of serotonin, which increases a woman’s risk of developing depression and insomnia. About twice as many women than men suffer from depression. A contributing factor might well be estrogen and oral contraceptive use, which deplete nutrients that influence mental health. Since vitamin B₆ is also necessary to metabolize homocysteine, a deficiency can result in elevated homocysteine levels and increase women’s risk of developing atherosclerosis (clogged arteries).

Oral contraceptives have been implicated in lowered levels of vitamins B₁, B₂, B₃, and B₁₂. A deficiency of vitamin B₁ can result in depression, irritability, memory loss, muscle, weakness, and edema, while vitamin B₂ deficiency pri-marily affects the skin, eyes, and mucous, membranes of the gastrointestinal tract. Vitamin B₃ deficiency from contraceptives may explain why twice as many women die from pellagra (lack of B₃) than men do. Symptoms include problems with the skin, gastrointestinal tract, and nervous system. As for vitamin B₁₂, supplementation should be considered because B₁₂ is required for the metabolism of homocysteine.

Women taking oral contraceptives have lower vitamin C (ascorbic acid) levels than women who do not, which can result in a weakened immune system, slower wound healing, and, increased risks for diseases such as cervical dysplasia, asthma, cancer, and, cardiovascular disease.

Oral contraceptives also deplete the minerals magnesium, selenium, and zinc. Although critical magnesium deficiency is rare in North America, marginal deficiency appears to be widespread, with symptoms including muscle cramps, weakness, insomnia, anxiety, nervousness, osteoporosis, and increased risk of cardiovascular problems.

A deficiency of selenium weakens the immune system, which can result in increased risk for viral infections, cancer, and cardiovascular disease. As a trace element, selenium is essential for adequate antioxidant defense. Therefore, lack of selenium may cause increased free radical damage and accelerated aging.

Ross Pelton, RPh, PhD, CCN, is a pharmacist and certified clinical nutritionist with a PhD in psychology and six books to his credit. Dr. Pelton is a member of the Medical Advisory Board for the Life Extension Foundation, and in October 1999 was named as one to the top 50 most influential pharmacists in the United States by American Druggist magazine.

Source: alive #252, October 2003