How fats and sugars can cause nonalcoholic fatty liver disease
Emily Kennedy MSc RHN
The obesity epidemic is fuelling a dangerous health condition called nonalcoholic fatty liver disease or NAFLD. Learn what steps you can take to prevent NAFLD.
Heart disease, diabetes, cancer; we’re constantly hearing about these obesity-related diseases. However, the obesity epidemic is fuelling another dangerous condition that we rarely hear about. It’s called nonalcoholic fatty liver disease (NAFLD), and it affects an estimated 1.4 million Canadians—too many to ignore.
Liver disease used to be associated with alcoholism, but a wide range of liver disorders affect teetotallers too.
Poor eating habits
The fatty liver that occurs in non-drinkers often starts with the overconsumption of fats and sugars. Prolonged poor eating habits may eventually lead to insulin resistance, a prediabetic state, which may also trigger a breakdown of the fat surrounding the liver so that it infiltrates the organ.
Insulin resistance also causes the liver to produce more fat in the form of triglycerides, which it then must store. When the fat content of the liver exceeds 5 to 10 percent of the liver’s weight, it is officially called NAFLD.
The stages of NAFLD
The initial stage of NAFLD is termed steatosis, in which fat simply builds up in the liver but doesn’t do much harm. If a high fat and sugar intake or exposure to other toxic substances continues to push the limits of the liver’s ability to function properly, obesity will start to manifest itself both externally and internally. The waistline expands while fat continues to accumulate in the liver.
Nonalcoholic steatohepatitis (NASH)
Eventually, the excess fat and toxins trigger inflammation in the liver, a condition known as nonalcoholic steatohepatitis (NASH). An inflamed fatty liver is considered a red flag, as 20 percent of people with NASH develop cirrhosis of the liver.
The most serious progression of NAFLD, cirrhosis is characterized by the formation of scar tissue (fibrosis). Unfortunately, this is irreversible, permanently compromising liver function.
What does the liver do?
The liver is a stalwart workhorse. It will continue to process everything we put in our mouths or on our skin even if many of its cells are damaged. It is also the only internal organ that can regenerate itself if it is partly severed.
In addition to dealing with all the toxins that enter our bloodstream, the liver is also our “director of metabolism,” regulating over 500 hormonal reactions involved in the storage and breakdown of fats, protein, and carbohydrates. Herein lies the complex connection between common metabolic disorders such as diabetes and liver health.
A liver’s efforts to properly regulate blood levels of fat (triglycerides), blood sugar (glucose), and certain amino acids are thwarted by fat and toxic buildup, like a car spinning its wheels in a muddy ditch. And if NAFLD progresses to NASH then cirrhosis, scar tissue will block blood flow in the liver, further slowing important detoxification processes, and fat and carbohydrate metabolism.
It’s no coincidence that people with high cholesterol, high triglycerides, or type 2 diabetes often have fatty livers. Indeed, a new study has concluded that fatty liver may be an independent risk factor for type 2 diabetes.
Researchers have also found a strong association between NAFLD and heart disease. Like some heart disease risk factors, it is often a silent condition with no obvious symptoms.
NAFLD is diagnosed by performing a blood test to identify elevated liver enzymes, an ultrasound examination, or a liver biopsy.
Respect your liver
As you may have guessed, a lifestyle that prevents development of a fatty liver is very similar to one that prevents heart disease and diabetes.
Make these basic lifestyle choices for a healthy liver:
Even people who aren’t overweight may develop a fatty liver from poor diet, making this one of the most important preventive strategies. Feed your liver the nutrients it needs without burdening it with excess fat and sugar.
(In the popular 2004 docudrama Super Size Me, Morgan Spurlock’s prolonged excessive intake of fat and refined carbs from fast food resulted in the preliminary stages of NAFLD even though clinically he was still considered a healthy weight.)
Despite the benefits provided by some substances, use medications and supplements judiciously. Natural or not, everything has to be processed by your liver, so take medications and supplements under the supervision of a health care practitioner.
Curb your anger
Both Chinese and Ayurvedic medical traditions view the liver as “the seat of anger.” An excess of this emotion is associated with fatty liver disease and other liver ailments.
Supplement your liver
In addition to a healthy diet, you can also care for your liver with the following supplements.
The active component of this Mediterranean weed, silymarin, is thought to help liver cells repair themselves after exposure to toxins. In animal studies milk thistle was found to reduce liver damage from acetaminophen use, iron overload, and alcohol consumption. Available as a capsule or tincture, milk thistle should be taken under professional supervision to avoid adverse effects.
Another weed traditionally used to treat the liver and kidneys, dandelion root has been used for thousands of years in Chinese medicine as a detoxifying agent and diuretic. Modern studies suggest that dandelion reverses hepatitis-induced symptoms by reducing inflammation so that the liver can heal itself.
Get the benefits of red wine without the toxic effects of alcohol. Promising animal studies show that this potent antioxidant can decrease the inflammatory response and reduce fat deposits in the liver.
Beets or beetroot juice
Beets are among the most detoxifying foods you can eat, so reduce the load on your liver by enjoying them regularly. There’s evidence that the betaine compounds in beets can protect the liver when it is under duress.
Men’s health across the life course
Theodore D. Cosco, PhD (Cantab) CPsychol